Changes of calpain activity in postmortem meat of pig 豬宰后肌肉中鈣激活蛋白酶活性變化的研究
The effect of focal cerebral ischemic preconditioning on the calpain activity in rats 2表達(dá)及細(xì)胞凋亡的影響
Elevation of intracellular calcium ions may be partly induced by increased influx through sarcolemma l type - calcium channels . intracellular calcium elevation , on one hand , would activate calpain , a calcium - dependent cysteine protease that degrade the myofibrillar proteins and cause muscle atrophy ; on the other hand , result in activation of calcineurin which enhance the activity of mhc i promoter and inhibit a shift of mhc isoforms from slow to fast in soleus 這樣,可能使得萎縮比目魚肌細(xì)胞內(nèi)鈣離子水平升高,細(xì)胞內(nèi)鈣離子靜息濃度的增加一方面激活calpain ,增加收縮蛋白的降解,使肌肉萎縮;草四軍醫(yī)大月卜祠成士學(xué)位論文另一方面通過激活鈣調(diào)神經(jīng)磷酸酶,增加快型mhc基因的表達(dá),使骨骼肌肌球蛋白重鏈( mhc )發(fā)生由慢型向快型的轉(zhuǎn)化。