Recent advances in biomedical research , such as vascular growth factors , clonality of hemangioma endothelial cells , immunophenotype , endothelial progenitor cells ( epcs ) , somatic mutations of ih , provide insights into a deeper understanding of the etiology of the tumor of childhood 近年來對(duì)與該病相關(guān)的血管形成生長(zhǎng)因子、單克隆生長(zhǎng)、免疫表型、內(nèi)皮祖細(xì)胞、基因缺陷等多方面進(jìn)行了較深入的研究。
The relation of ( he diversity to clonality was determined by conal architecture , control mechanism among ramets and habitat conditions . in general , the relation between shannon - wiener index and importance of clonal plants was positive in plant - spare habitats , but negative in plant - dense habitats 群落中克隆性與多樣性的關(guān)系同植物的克隆生長(zhǎng)構(gòu)型和克隆植物種群內(nèi)部的調(diào)節(jié)機(jī)制,以及植物的生境狀況有關(guān)系。
It still remains a question whether the rearrangements of igh come from h / rs cell or the background lymphocytes . in this study , we have detected the igh clonal correlation between the h / rs cells and the background cells , from a new aspect to study the clonality of h / rs cell and its relation with the background cells . the expression of b - cell - specific activator protein ( bsap ) was detected in hl . igh gene rearrangements were analysed by the methods including gene analysis in neoplasms tissue and micropicked cells from paraffin - embedded sections , sequencing to test the pcr product , and in situ pcr 本研究將在以往研究的基礎(chǔ)上,在國(guó)內(nèi)率先把b細(xì)胞核反式作用因子? b細(xì)胞特異性激活蛋白( b - cell - specificactivatorprotein , bsap )應(yīng)用于hl的研究,檢測(cè)hl的bsap表達(dá),并采用石蠟刮片組織和微切割單細(xì)胞的基因分析、測(cè)序分析和間接原位pcr等方法,同步觀察分析h rs和背景淋巴細(xì)胞的igh基因克隆相關(guān)性,從又一個(gè)新視角探究chl的腫瘤性h rs細(xì)胞克隆性及與背景淋巴細(xì)胞的關(guān)系。