Many studies have been carried out on the toxicity of pollutants to aquatic animals , most of them are focused on the information of lethal concentrations , few have concerned the effects of sublethal concentration on the metabolism conditions 在污染物對于水生生物的毒害作用方面已經(jīng)進行了大量的研究,但是大多為毒物致死濃度方面的報道,而關(guān)于在亞致死濃度時它們對于機體的生理影響卻很少報道。
Investigations were carried to assess the sublethal effects of the insecticides ( fipronil and triazophos ) and the heavy metals ( cd2 + and pb2 + ) on activities of brain acetylcholinesterase ( ache ) , hepatic glutathione - s - transferases ( gst ) and liver esterases in pseudorosbora parva 處理在24h時的抑制率為79 . 5 ,是三唑磷的近4倍、處理iv的1 . 6倍,但在48h后,處理i 、處理iv和三哩磷的抑制率基本接近。
Nci - h1155 , a human non - small - cell lung cancer line , was employed in a paclitaxel - dependent synthetic lethal screen designed to identify gene targets that specifically reduce cell iability in the presence of otherwise sublethal concentrations of paclitaxel Nci - h1155作為一種人類非小細胞肺癌的種株,可運用其在依賴紫杉醇殺傷性藥物合成過程中設(shè)計鑒別出靶基因,從而特異性減少未達到殺傷性致死量的紫杉醇藥物作用后腫瘤細胞仍存活的數(shù)量。
The experiment includes two procedure . first , sd rats were conditioned with 5 . 5gy sublethal total body irradiation ( tbi ) , followed by infusion of balb / c mice bone marrow cells 8x107 on day 0 , then were intraperitonially administered cyclophosphamide ( cp ) 150mg / kg on day 2 . the procedure let sd rats become chimerism and have specific immunologic tolerance 實驗分兩步:第一步, sd大鼠經(jīng)亞至死劑量5 . 5gy全身照射后,尾靜脈輸入balb c小鼠的骨髓細胞8 10 ~ 7 , 2天后腹腔內(nèi)注射環(huán)磷酰胺150mg kg ,誘導形成嵌合體大鼠,使其對balb c小鼠產(chǎn)生特異性免疫耐受。
Poiycyclic aromatic hydrocarbons ( pah ) are priority trace organic pollutants in the clrtap ( convention on long - range transboundary air poliution ) pops ( persistent organic poilutants ) protocol . both laboratory experiments and fie1d surveys unequivocally demonstrated that pah adversely affect estuarine and marine organisms . pah are implicated in the development of iesions and tumors in fish , they produce biochemical disruptions and cell damage that iead to mutations , developmental malformations and cancel although many marine organisms do not exhibit acute responses to pah " exposure , but suffer sublethal effects 本論文以湄洲灣海域和廈門西海域養(yǎng)殖區(qū)為研究區(qū)域,采用現(xiàn)代分析技術(shù),從分子水平上系統(tǒng)研究了多環(huán)芳烴( pah )在海水、沉積物、養(yǎng)殖魚類中的含量分布:通過現(xiàn)場實驗,實驗室暫養(yǎng)、投毒和恢復(fù)實驗系統(tǒng)測定了養(yǎng)殖魚類的肝臟、膽汁、鰓、全血等不同器官、組織的生化指標及養(yǎng)殖魚類肝臟、膽汁的化學指標,探討了這些指標對水環(huán)境多環(huán)芳烴污染的生物指示作用。