These data showed that the chimerism were specially tolerant to donor xenoantigens in skin grafting and mixed lymphocyte reaction ( mlr ) assays , however were still immunocompetent to mhc - disparate third party c57bl / 6 mouse . in the second experiment , mice of group b appeared with variant degree of wasting , diarrhea , fur losing , and all died within 15 days . pathologic changes of liver and intestine were inflamming cells infiltrating and necrotizing 肝、小腸切片均有明顯病理改變,主要表現(xiàn)為腸粘膜部分脫落、壞死和炎性細胞浸潤,肝實質(zhì)內(nèi)有灶性淋巴細胞及多形細胞浸潤,并可見局灶性壞死,兩者均符合gvhd病理改變。