monooxygenases,microsomal 《英文msh詞典》Monooxygenases,Microsomal ; [入口詞] Monooxygenases,Microsomal ; [主題詞] Aryl Hydrocarbon Hydroxylases ; [英文釋義] A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids,drugs,and toxins such as PHENOBARBITAL,carcinogens,and insecticides.
monooxygenase,tryptophan 《英文msh詞典》Monooxygenase,Tryptophan ; [入口詞] Monooxygenase,Tryptophan ; [主題詞] Tryptophan Hydroxylase ; [英文釋義] An enzyme that catalyzes the hydroxylation of tryptophan to 5-hydroxytryptophan in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of serotonin. EC 1.14.16.4
monooxygenases,steroid 《英文msh詞典》Monooxygenases,Steroid ; [入口詞] Monooxygenases,Steroid ; [主題詞] Steroid Hydroxylases ; [英文釋義] Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
monooxygenase,sparteine 《英文msh詞典》Monooxygenase,Sparteine ; [入口詞] Monooxygenase,Sparteine ; [主題詞] Cytochrome P-450 CYP2D6 ; [英文釋義] A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals,such as DEBRISOQUINE,ADRENERGIC RECEPTOR ANTAGONISTS,and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
monooxygenases,xenobiotic 《英文msh詞典》Monooxygenases,Xenobiotic ; [入口詞] Monooxygenases,Xenobiotic ; [主題詞] Aryl Hydrocarbon Hydroxylases ; [英文釋義] A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids,drugs,and toxins such as PHENOBARBITAL,carcinogens,and insecticides.
monooxygenase,monophenol 《英文msh詞典》Monooxygenase,Monophenol ; [入口詞] Monooxygenase,Monophenol ; [主題詞] Monophenol Monooxygenase ; [英文釋義] An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine,L-dopa,and oxygen to yield L-dopa,dopaquinone,and water. It is a copper protein that acts also on catechols,catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.
monooxygenase,cytochrome p-450-dependent 《英文msh詞典》Monooxygenase,Cytochrome P-450-Dependent ; [入口詞] Monooxygenase,Cytochrome P-450-Dependent ; [主題詞] Cytochrome P-450 Enzyme System ; [英文釋義] A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum,from animals,plants,fungi,to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals,these P-450 enzymes serve two major functions: (1) biosynthesis of steroids,fatty acids,and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates,such as toxins and drugs (BIOTRANSFORMATION). They are classified,according to their sequence similarities rather than functions,into CYP gene families (>40% homology) and subfamilies (>59% homology). For example,enzymes from the CYP1,CYP2,and CYP3 gene families are responsible for most drug metabolism.
monooxygenase,cytochrome p-450 《英文msh詞典》Monooxygenase,Cytochrome P-450 ; [入口詞] Monooxygenase,Cytochrome P-450 ; [主題詞] Cytochrome P-450 Enzyme System ; [英文釋義] A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum,from animals,plants,fungi,to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals,these P-450 enzymes serve two major functions: (1) biosynthesis of steroids,fatty acids,and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates,such as toxins and drugs (BIOTRANSFORMATION). They are classified,according to their sequence similarities rather than functions,into CYP gene families (>40% homology) and subfamilies (>59% homology). For example,enzymes from the CYP1,CYP2,and CYP3 gene families are responsible for most drug metabolism.
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例句與用法
Recently, the chinese plant protection agencies reported the growing hardships in controlling some field populations of oriental migratory locust with organophosphate ( op ) compounds . up to now there are more than 600 arthropod species with documented resistance to one or more insecticides and / or acaricides since resistance phenomenon was first described in san jose scale to lime-sulfur in washington in 1908 . enhanced metabolic detoxification and reduced sensitivity of insecticide target-sites are the two major mechanisms in resistance development, involving three primary metabolic enzymes of esterases, glutathione s-transferases and cytochrome p450 polysubstrate monooxygenases 代謝抗性是指對(duì)殺蟲劑起水解或隔離作用的酶發(fā)生改變,從而對(duì)殺蟲劑起到解毒作用,昆蟲主要解毒酶系有酯酶、谷胱甘肽-s-轉(zhuǎn)移酶、細(xì)胞色素p450單加氧酶等,這三種酶系任何一種的組成部分發(fā)生改變均會(huì)引起害蟲抗性的改變;靶標(biāo)抗性是指由于殺蟲劑作用靶標(biāo)敏感度降低而產(chǎn)生的抗性。