macrocyclization造句
例句與造句
- The G protein is also responsible for macrocyclization.
- The distinctive nature of this class is not only the relatively large size of the natural products but also the modifying enzymes responsible for macrocyclization.
- While the mechanism of macrocyclization is not known, the nitrogenous ring can exist in thiopeptides as a piperidine, dehydropiperidine, or a fully oxidized pyridine.
- Enterocin AS-48 was isolated from " Enterococcus " and, like other bacteriocins, is relatively resistant to high temperature, pH changes, and many proteases as a result of macrocyclization.
- For example, we have found that nickel catalyzed reactions are compatible with a wide array of functional groups, making them useful in complex settings, such as fragment coupling or macrocyclization operations at a late stage in synthesis.
- It's difficult to find macrocyclization in a sentence. 用macrocyclization造句挺難的
- Elongation by these NRPS modules ultimately leads to macrocyclization and release in which an ?-amino group, namely threonine, acts as an internal nucleophile during cyclization to yield the 10-amino-acid ring ( Figure 6 ).
- Polypyridine complex "'43 "'was treated with N-Bromosuccinimide in wet tetrahydrofuran followed by pyridine to generate the acylmethylpyridinium salt "'44 "'which can then undergo the macrocyclization under standard conditions to yield the desired product "'45 " '.
- Kelly and co-workers developed a route to cyclo-2, 22 : 42, 42 2 : 22 2, 22 2 2 : 42 2 2, 42 2 2 2 : 22 2 2 2, 22 2 2 2 2 : 42 2 2 2 2, 4-sexipyridine utilizing the Kr鰄nke reactions as the key macrocyclization step.
- In the first step of this macrocyclization the thiol group in one end of " 1, 5-pentanedithiol " reacts with the butadiene tail in "'1 "'to the enone "'2 "'in an allylic shift with a sulfone leaving group which reacts further with the other end in a conjugate addition reaction.
- Interestingly, the precursor peptide of the cyanobactin family is traditionally designated the " E " gene, whereas precursor peptides are designated gene " A " in most RiPP gene clusters . " A " is a serine protease involved in cleavage of the leader peptide and subsequent macrocyclization of the peptide natural product, in combination with an additional serine protease homologue, the encoded by gene " G . " Members of the cyanobactin family may bear thiazolines / oxazolines, thiazoles / oxazoles, and methylations depending on additional modification enzymes.