resolvins造句
造句與例句
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- CMKLR1, GPR32, and FPR2 have been proposed to be the GPR through which these resolvins act.
- Metabolically stable analogs of the SPMs, including the resolvins, are in development and being tested in volunteers with chronic inflammation-related diseases.
- The eicosapentaenoic acid found in fish oils appears to dramatically reduce inflammation through conversion within the body to resolvins, with beneficial effects for the cardiovascular system and arthritis.
- There are multiple subfamilies of eicosanoids, including most prominently the prostaglandins, thromboxanes, leukotrienes, lipoxins, resolvins, and eoxins but also others as noted in the following Nomenclature section.
- While all of the resolvins possess one or more anti-inflammatory activity as accessed on in vitro model systems, not all of the resolvins have been studied for activity in vivo as long or as thoroughly as RvE1 and RvD1.
- While all of the resolvins possess one or more anti-inflammatory activity as accessed on in vitro model systems, not all of the resolvins have been studied for activity in vivo as long or as thoroughly as RvE1 and RvD1.
- However, the most studied and accepted role for FPR2 receptors is in mediating the actions of the cited lipoxins and resolvins in dampening and resolving a wide range of inflammatory reactions ( see lipoxin, Epi-lipoxin, and resolvin ).
- Both receptor types bind and are activated by a series of formylated oligopeptide chemotactic factors but FLP2 receptor appears to be a promiscuous receptor in that it also binds to and is activated by lipoxins and resolvins as well as various polypeptides and proteins.
- "' Resolvins "'are autacoids of a specific lipid structure : dihydroxy or trihydroxy metabolites of omega-3 fatty acids, primarily eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ) but also the docosapentaenoic acid ( DPA ), clupanodonic acid.
- Resolvin E1 ( RvE1 ), RvD2 ( see resolvins ), neuroprotectin D1 ( NPD1 ), and maresin 1 ( Mar1 ) are metabolites of the omega 3 fatty acids, eicosapentaenoic acid ( for RvE1 ) or docosahexaenoic acid ( for RvD2, NPD1, and Mar1 ).
- It's difficult to see resolvins in a sentence. 用resolvins造句挺難的
- By metabolizing ?-3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, into lipoxins and resolvins, 15-LOX-1 is thought to be one mechanism by which dietary ?-3 polyunsaturated fatty acids, particularly fish oil, may act to reduce the incidence and / or progression of certain cancers.
- At least 6 members of the D series of resolvins ( RvDs ) viz ., RvD1, RvD2m AT-RVD1, RvD3, AT-RvD3, and RvD5, activate their target cells through this receptor; these results have led to naming GPR32 the RVD1 receptor ( see Resolvin # Mechanisms of Action ).
- For example, ALOX5 acts with ALOX12 or aspirin-treated COX-2 to metabolize arachidonic acid to lipoxins and with cytochrome P450 monooxygenase ( s ), bacterial cytochrome P450 ( in infected tissues ), or aspirin-treated COX2 to metabolize eicosapentaenoic acid to the E series resolvins ( RvEs ) ( see Specialized pro-resolving mediators ).
- The following oxygenase enzymes are responsible for metabolizing PUFA to resolvins : 15-lipoxygenase-1 ( i . e . ALOX15 ), possibly 15-lipoxygenase-2 ( i . e . ALOX15B ), 5-lipoxygenase ( i . e . ALOX5 ), cyclooxygenase-2 ( i . e . COX-2 ), and certain Cytochrome P450 monooxygenases.
- By metabolizing the ?-3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, into 17-HpDHA, 17-HDHA, and the resolvins and protectins, 15-LOX-1's metabolic action is thought to be one mechanism by which dietary ?-3 polyunsaturated fatty acids, particularly fish oil, act to ameliorate inflammation, inflammation-related diseases, and certain cancers.
- The D series resolvins ( i . e . RvD1, RvD2, RvD3, RvD4, RvD5, RvD6, AT-RVD1, AT-RVD2, AT-RVD3, AT-RVD4, AT-RVD5, and AT-RVD6 ) are specialized pro-resolving mediators that contribute to the resolution of inflammation, promote tissue healing, and reduce the perception of inflammation-based pain ( see resolvins ).
- The D series resolvins ( i . e . RvD1, RvD2, RvD3, RvD4, RvD5, RvD6, AT-RVD1, AT-RVD2, AT-RVD3, AT-RVD4, AT-RVD5, and AT-RVD6 ) are specialized pro-resolving mediators that contribute to the resolution of inflammation, promote tissue healing, and reduce the perception of inflammation-based pain ( see resolvins ).
- Furthermore, aspirin, while inhibiting the ability of COX-2 to form pro-inflammatory products such as the prostaglandins, converts this enzyme's activity from a prostaglandin-forming cyclooxygenase to a lipoxygenase-like enzyme : aspirin-treated COX-2 metabolizes a variety of polyunsaturated fatty acids to hydroperoxy products which are then further metabolized to specialized proresolving mediators such as the aspirin-triggered lipoxins, aspirin-triggered resolvins, and aspirin-triggered maresins.
- *Resolvin Ds ( RvDs ), i . e . RvD-1, RvD2, RvD3, RvD4, RvD5, and RvD6 ( see resolvin and specialized proresolving mediators # DHA-derived Resolvins ) and protetin Ds ( PDs ), i . e . PD1, PDX, 20-hydroxy-PD1, 17-epi-PD1, and 10-epi-PD1 ( see neuroprotectin D1 and specialized proresolving mediators # DHA-derived protectins / neuroprotectins ).
- Specialized pro-resolving mediators are cell-derived metabolites of certain polyunsaturated fatty acids viz . : arachidonic acid which is metabolized to the lipoxins; eicosapentaenoic acid which is metabolized to the Resolvin E's; docosahexaenoic acid which is metablized to the Resolvin D's, Maresins, and Neuroprotectins; and n-3 docosapentaenoic acid which is metabolized to the n-3 docosapentaenoic acid-derived resolvins and n-3 docosapentaenoic acid-derived neuroprotectins ( See Specialized pro-resolving mediators ).
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