7 of 12 strains having small deletions showed low level isoniazid resistant including 6 strains at 1716 bp position deletion , and 1 isolates having insertion showed high level isoniazid resistant 12株發(fā)生缺失的菌株中, 7株對(duì)異煙肼低度耐藥,其中6株是1716位堿基缺失的菌株;發(fā)生堿基插入的唯一1株細(xì)菌對(duì)異煙肼高度耐藥。
An ser - to - ala substitution at position 94 was detected in 2 isolates showing low level isoniazid resistant , an ile - to - thr substitution at posotion 21 was found in 2 isolates showing high level isoniazid resistant , and small deletion was identified in 1 isolates showing high level isoniazid resistant 94位氨基酸突變的2株細(xì)菌低度耐藥, 21位氨基酸突變的2株細(xì)菌高度耐藥,堿基缺失的細(xì)菌高度耐藥。 43株異煙肼敏感株中沒(méi)有檢測(cè)到inha基因突變。
However , the cloned promoter had 18 substitution at 18 sites , 22 deletions at 18 sites and 3 insertion at 3 sites between sites 0 - - - 1273 bp which was reported to control temporal - spatial specific expression , and 3 substitution at 3 sites , 6 deletions at 6 sites between - 1095 bp and - 1273 bp , the key functional sequence area , in comparing with known osg6b 但是與報(bào)道的osg6b比較,在決定時(shí)空特異性的0 - 1273bp功能區(qū)域內(nèi),有18處出現(xiàn)18堿基替換, 18處出現(xiàn)22堿基缺失, 3處出現(xiàn)3堿基插入;在核心功能序列區(qū)域( - 1095bp - 1273bp )內(nèi),有3處出現(xiàn)3堿基替換, 6處出現(xiàn)6堿基缺失。