潛能性 family coping: potential for growth; family coping:potential for growth; potential for enhance spiritual well-belug; potential for enhanced community coping
Stem cells make it possible to treat various human diseases owing to their self - renewal and the multiplex differentiation potential 摘要由于干細(xì)胞具有自我更新和多向分化潛能的功能,使得人們用干細(xì)胞治療多種疾病成為可能。
1 . bone marrow mscs are multipotent tissue stem cells that can be induced in vitro to differentiate into mesenchymal and non - mesenchymal cells 骨髓msc是一類存在于骨髓中的具有多向分化潛能的干細(xì)胞,體外不僅可以分化為間充質(zhì)類細(xì)胞,而且可以分化為非間充質(zhì)類細(xì)胞。
Marrow stromal cells are adult stem cells from bone marrow that have the potency to differentiate into multiple nonhematopoietic lineages such as bone , cartilage , and lipocyte et al . it also can differentiate into myocytes , hepatocytes , glial cells , and neurons . marrow stromal cell can be easily obtained and have a set of well - developed separation and culture techniques 背景與目的骨髓間充質(zhì)干細(xì)胞( mesenchymalstemcells , mscs )是具有多向分化潛能的成體干細(xì)胞,除了能向多種中胚層組織細(xì)胞分化,如骨軟骨和脂肪細(xì)胞外,還可以誘導(dǎo)分化成非中胚層的細(xì)胞組織如:神經(jīng)細(xì)胞,肺泡和小腸細(xì)胞。
In contrast to murine studies , studies of human hscs have relied on a number of in vitro assays that identify cells with the capacity to generate hematopoietic progenitors in long - term culture and to differentiation into multiple hematopoietic lineages . recently , two elegant animal models that enable the in vivo measurement of human hscs marrow repopulating potential have been developed . one is the sheep in utero transplantation system in which human hematopoietic progenitor cells are transferred into the sheep fetus in utero before the development of the ovine immune system 早在80年代中期, zanjani等就利用胚胎期免疫系統(tǒng)發(fā)育不完善,將人的造血干細(xì)胞移植到妊娠中期胚羊腹腔內(nèi),成功地建立了人胎羊造血干細(xì)胞嵌合體移植模型,并以此實(shí)驗?zāi)P妥鳛轶w內(nèi)檢測人造血干細(xì)胞和人骨髓間充質(zhì)干細(xì)胞多向分化潛能的方法。
Although bone marrow is the major source of adult hematopoietic stem cells ( hscs ) . it also contains another kind of stem cells - mesenchymal stem cells ( mscs ) . mesenchymal stem cells are thought to be multipotent cells , which have the potent to differentiate into lineages of mesenchymal tissues , including muscle , cartilage and fat 骨髓中除存在造血干細(xì)胞,還含有另一類干細(xì)胞? ?骨髓間充質(zhì)干細(xì)胞( mesenchymalstemcells , mscs ) ,其具有多向分化潛能,在不同的誘導(dǎo)條件下可分化為多種組織細(xì)胞,如成肌細(xì)胞,成骨細(xì)胞,脂肪細(xì)胞及其它類間充質(zhì)細(xì)胞。