Influence of heat stress on ampk activity and lipid metabolites of piglets hepatocytes in vitro 活性及脂質代謝產物的影響
Mice given clozapine showed quadrupled ampk activity compared to activity measured pre-drug 鼠給藥后顯示ampk活性是使用以前藥物的四分之一。
The researchers then gave the mice leptin, a hormone that suppresses appetite, and as suspected, saw lowered ampk levels 研究者之后給小鼠抗肥胖藥來普汀,一種抑制食欲的激素,正如推測的一樣,ampk水平降低。
The team found that inducing ischemia in isolated murine hearts triggered mif release, leading to ampk activation and impaired downstream glucose uptake 研究小組發(fā)現(xiàn),誘導離體鼠心肌缺血觸發(fā)了mif的釋放,導致ampk活化下游葡萄糖攝取受損。
To confirm that the histamine receptor connects the drug, ampk activity and appetite, the team gave clozapine to mice genetically engineered without a histamine receptor 為證實組胺受體和藥物、ampk活性、和食欲相關,研究組給經遺傳重組后缺失去組胺受體的小鼠氯氮平藥物。
They demonstrate that under hypoxic conditions mif activates the cellular stress response enzyme amp-activated protein kinase ( ampk ), which in turn is a key regulator of metabolism protecting against ischemic damage 他們證實,在缺氧環(huán)境下mif激活細胞內應激反應酶腺苷酸活化蛋白激酶(ampk),它是隨后抗缺血損傷代謝調控的重要元素。
Suspecting that antipsychotic drugs might spike ampk in the brain to overact, the johns hopkins team injected mice with clozapine ( clozaril ), which, with olanzapine ( zyprexa ) and risperidone ( risperdal ), is commonly prescribed for schizophrenia and bipolar disorder in people who do poorly on conventional drugs 推測到腦中抗精神病藥物能激發(fā)ampk過度的活性,約翰霍普金斯研究小組將抗精神病藥物氯氮平聯(lián)合奧氮平和利哌酮注入小鼠,醫(yī)生常開出處方氯氮平給使用常規(guī)藥物藥效差的病人用于治療抗精神分裂癥、雙相性精神障礙。