They contribute to innate host defense against a number of bacterial and fungal pathogens , even some of the pathogens resistant to conventional antibiotics . more than 300 peptide antibiotics have been found so far , and some have natural or artificial mutants 迄今已從動物、植物、昆蟲等生物體內(nèi)分離到肽抗生素300多種,新的肽抗生素還在不斷被發(fā)現(xiàn),有的類別還發(fā)現(xiàn)存在多種突變體。
Ii ) the renaturation of synthetic hpab was carried out in glutathione oxidation / reduction solution ( l : 10 ) . the renatured synthetic hpab could kill escherichia coli , pseudomonas aeruginosa and staphylococcus aureus on lb agar plates . thirdly , construction of artificial mutants of hpab 3 .突變體的設(shè)計及其重組桿狀病毒構(gòu)建:采用同源模建法分析hpab一p的空間結(jié)構(gòu),并以此結(jié)構(gòu)為基礎(chǔ),設(shè)計hpab一p突變體hpab一p38和hpab一p34 。