Our goal is to establish a simple and effective empirical approach to calculate the conformational entropy and the binding free energy by analysis of j : protein interface . three variables of the binding interface information of 20 protein complexes , including the binding accessible number ( nb ) , hydrophilic pair ( n ^ , ) and apolar solvent - accessible surface areas ( & asaapol ) are analyzed 本論文在此分析了20組蛋白質(zhì)二聚體分子的結(jié)合界面三個(gè)有效的參數(shù)信息,即界面殘基側(cè)鏈可接觸數(shù)( n _ b ) 、親水對(duì)數(shù)( n _ ( pair ) )和非極性溶劑可接近表面積的變化( asa _ ( apol ) ) 。