The nr2b subunit have a long cytoplasmic tail ( 644aa ) , so it predicts that there may be some functional domains in this tail Nrzb含有很長的胞內(nèi)區(qū)( 644個氨基酸) ,推測它們很可能存在許多重要的功能區(qū)和調(diào)節(jié)位點。
A change in functional properties of the nmda receptors has been invoked as a potential mechanism contributing to the loss of synaptic plasticity during brain maturation . from this , it is important to well understand the structural and functional diversity of nmda receptors in relation to nmda receptor subunit composition and spatial distribution at excitatory synaptic sites during development 近幾年來,在哺乳動物中樞神經(jīng)系統(tǒng)中,對離子型谷氨酸受體如何定位到興浙江大學醫(yī)學院碩士論文nrzb亞單位的c末端胞內(nèi)區(qū)影響n協(xié)da受體裝配、運鈞以及表面表達的分子機制奮性突觸的研究有了長足的發(fā)展。
On the other hand , our previous studies have shown that the nr2b construct with a gfp tag in its n - terminus cotransfected with nr1 subunit can reach the cell surface and be detected by surface staining with anti - gfp antibody in live cells . the nr2b construct will be retained in the endoplasmic reticulum ( er ) when expressed alone in heterologous cells 我們以往的研究表明,用綠熒光蛋白( gf內(nèi)在信號膚下游n末端標記nrzb亞單位,與nri共轉(zhuǎn)染時能形成與野生型相似的nmda受體通道,且可以通過抗gfp抗體標記活細胞膜表面表達的nmda受體復合物。