hap1造句
- The new protein was named HAP1, for huntingtin associated protein 1.
- The function of HAP1 is not known, Ross said.
- HAP1 preferentially interacts with muHtt in a polyQ dependent manner.
- The subcellular location of HAP1 closely resembles that of Htt.
- Cells in those regions may be especially vulnerable to whatever it is that HAP1 and mutant huntingtin do together.
- HAP1 is found in areas of the brain known to be affected in Huntington's disease, Ross said.
- HAP1 also interacts with proteins other than Htt and it is likely that their function is altered in HD pathogenesis.
- More importantly, HAP1 may also disrupt endocytosis, as it has been detected on vesicles involved in the early stages of this process.
- It is possible that the non-pathogenic activity of HAP1 is intracellular trafficking and that this is perturbed following its association with mHtt.
- They did not find HAP1 labeling in protein aggregates in the cytoplasm and postulated that this indicated HAP1 in pre-aggregate related HD pathogenesis.
- It's difficult to see hap1 in a sentence. 用hap1造句挺難的
- They did not find HAP1 labeling in protein aggregates in the cytoplasm and postulated that this indicated HAP1 in pre-aggregate related HD pathogenesis.
- The possible significance of this interaction is that increased HAP1 interaction with muHtt may also increase nitric oxide ( NO ) thus facilitating neuronal damage.
- The nice part of this work is that the same assay that found HAP1 binding to huntingtin could be used to screen drugs, Ross said.
- The role of HAP1 in HD pathogenesis may involve aberration of cell cycle processes, as high immunostaining of HAP1 during the cell cycle has been observed.
- The role of HAP1 in HD pathogenesis may involve aberration of cell cycle processes, as high immunostaining of HAP1 during the cell cycle has been observed.
- HAP1 also shows a similar CNS distribution pattern to that of neural nitric oxide synthase ( pedunculopontine nuclei, the supraoptic nucleus, and the olfactory bulb.
- Gutekunst and colleagues used immunogold labeling to identify subcellular localization of both HAP1 and muHtt, and identified a close similarity of the distribution of the two proteins.
- Martin et al . showed that HAP1 is localized in mitotic spindle of dividing striatal cells, and associated endosomes, microtubules and cortex, including the anterior cingulate cortex and the limbic cortex.
- Over 100 interacting proteins have been found, such as huntingtin-associated protein 1 ( HAP1 ) and huntingtin interacting protein 1 ( HIP1 ), these were typically found using two-hybrid screening and confirmed using immunoprecipitation.
- Interacting proteins found using two-hybrid screening techniques include GIT1; a G protein-coupled receptor kinase interacting ArfGAP, the cytoplasmic protein HAP1; Huntingtin-associated protein 1, IMMT, an inner mitochondrial membrane protein, and PFN2; Profilin 2-ubiquitous actin monomer binding protein.