In mice the h-2 isoantigens are the strongest histocompatibility antigens . 小鼠中的H-2同種抗原是最強(qiáng)的組織相容性抗原。
In mice the h - 2 isoantigens are the strongest histocompatibility antigens 小鼠中的h - 2同種抗原是最強(qiáng)的組織相容性抗原。
On the other hand , there is substanial evidences tha dcs mediate tolerane . the gm - csf - stbolated mouse bone mwderived mhc class ii + dc progendors tha are deficient in cell surface erpression of the costbolatory molecules b7 - l and b7 - 2 can induce alloanginspecific t ceil anergy in vbo . systendc adchstraion of these donor - derived dc progendors to recipients intravenously 7 days before transplantation prolonged the median graft survival tane from 9 . 5 days to 22 days wbout additional twnosuppressions in a mouse cardinc twlanation model 1995年, lul等報(bào)道表面缺乏共刺激分子,特別是缺乏cd80 ( b7 - 1 )和cd86 ( b7 - 2 )的未成熟型dc能在體外誘導(dǎo)同種抗原特異性的t細(xì)胞無(wú)能,而對(duì)dc的適當(dāng)處理能夠使未成熟型dc潛在的耐受原性得以放大和增強(qiáng),使得dc在誘導(dǎo)免疫耐受中具有相當(dāng)重要的作用及潛在的應(yīng)用價(jià)值。